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李怡萱教授學術分享--失智症與腦發育及退化研究
 



    李怡萱
   (Yi-Hsuan Lee, PhD)    
                            

    現職: 國立陽明大學生理學研究所教授
   (Physiology, National Yang-Ming University)
 



研究領域與興趣 (Research Interest)
  1. 基因與環境交互作用於失智症與情緒障礙之致病機轉 (Mechanisms of gene-environment interaction in the pathogenesis of dementia and mental disorders)
  2. 神經元與膠細胞交互作用於腦發育與退化過程之整合機轉 (Integrative mechanisms of neuron-glia interaction in brain development and degeneration)
 
最新發現
 
  1. Aryl hydrocarbon receptor (AhR), the receptor for environmental hormones, can be activated by proinflammatory insult in the absence of external ligands in microglia to regulate neuroinflammation. (Lee et al., GLIA, 2015. https://www.ncbi.nlm.nih.gov/pubmed/25690886)
 
  1. Growth-associated protein 43 (GAP43) functions as a new indicator for beneficial astrogliosis. (Hung et al., J Neurosci., 2016. https://www.ncbi.nlm.nih.gov/pubmed/26865625)
 
  1. Growth-associated protein 43 (GAP43) functions to regulate clustering and folding of gephyrin, the postsynaptic scaffolding protein for GABAA receptor, in developing brain. (Wang et al., Mol. Cell. Biol., 2015. https://www.ncbi.nlm.nih.gov/pubmed/25755278)
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