姓名：余佳慧 教授
服務單位：臺灣大學醫學院生理研究所
學術分享： 腸道細菌影響上皮細胞免疫屏障和癌化之分子機制
E-mail: lchyu@ntu.edu.tw
 

專長學科	腸胃生理，黏膜免疫
學經歷	Professor, Graduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC
	Post-doctoral fellow, University of Calgary, Calgary, Alberta, Canada
	Ph.D., Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada
	M.Sc., Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
	B.Sc., Department of Veterinary Medicine, College of Agriculture, National Taiwan University, Taipei, Taiwan, ROC
研究方向及興趣	Our research interest is focused on host-microbe interaction for regulation of epithelial barrier function and tumorigenesis in the gastrointestinal tract. The intestinal epithelium acts as the first line of defense against commensal bacteria and microbial pathogens. Epithelial dysfunction and microbiota dysbiosis are involved in the pathogenesis of various gastrointestinal diseases, including inflammatory bowel disease, irritable bowel syndrome, and colorectal cancers. Specific microbial strains and bacterial lipopolysaccharide (LPS) are involved in colorectal tumorigenesis (Figure 1 and 2). Gene modified animal models, intestinal epithelial cell lines, primary organoids and spheroid cultures, as well as molecular techniques of site-directed mutagenesis, gene silencing and knockout are utilized in our laboratory to investigate the pathophysiological mechanisms of intestinal diseases.   Current research projects: Molecular mechanisms of regulation of epithelial tight junctions and bacterial transcytosis Identification of specific intestinal bacteria with barrier-breaking and pro-tumorigenic ability Cytoprotection and death resistance mechanisms by glucose on intestinal epithelium and colorectal carcinoma

 

Figure 1 Bacterial lipopolysaccharide (LPS) receptors had antagonist roles in regulation of intestinal epithelial cell death and survival, and its dysfunction contributed to colorectal tumorigenesis. (Kuo WT, Lee TC, and Yu LC. Molecular and Cellular Oncology, 2016)
 

Figure 2 A working model of reciprocal relationship between microbes and innate immunity in regulation of colorectal tumors. (Yu LC et al, Cancer Research Frontiers 2017)